Virogenetics
Krzysztof Pyrc’s virology group
science & application
In our work we combine the basic research and utilize it to carry out applicatory projects.
3D tissue models
To gain a deeper understanding of viral infections, we employ cutting-edge ex vivo culture systems, comprised of fully differentiated primary cells. This approach enables us to accurately reconstruct and study the virus within its natural infection microenvironment.
Virus and the cell
To accurately observe viruses within the context of their cellular environment, it’s crucial to employ the right tools. Therefore, we utilize a wide array of techniques ranging from confocal microscopy to advanced structural biology methods.
Relevance
We strive to thoroughly validate our results to guarantee their reliability. To achieve this, we have developed specialized models and employ a rigorous cross-checking process encompassing in vitro, in vivo, and ex vivo studies.
Antivirals
Science serves as our fundamental means to decipher the world. This pursuit of understanding not only satisfies our intellectual curiosity but also paves the way for practical applications, particularly in the realm of developing innovative therapeutic strategies.
Services
We are eager to assist you with our tools and extensive experience. If you’re interested in a collaborative partnership and wish to explore our services, please feel free to reach out to us!
Consulting
Having amassed considerable knowledge and expertise in virology, tissue engineering, and biosafety, we are enthusiastic about the opportunity to share our insights and discoveries with others.
Senior staff
We are dynamic & vibrant team driven by curiosity and passion.
Krzysztof Pyrć
Founder & PI
Aleksandra Milewska
Tissue cultures and respiratory tract
Katarzyna Owczarek
Interactom of the virus
Anna Kula-Pacurar
HIV virus and double-kick therapy
Natalia Mazur-Panasiuk
Environment and virus stability
Aneta Zegar
Antivirals
Artur Szczepanski
Animal viruses & research models
Dominika Birgiel-Pachalska
Project Manager
Junior staff
Emilia Barreto-Duran
co-cultures and gut organoids
Aleksandra Synowiec
CRISPR-Cas Screenings
Kevin Lie
Models for coronaviruses
Agnieszka Suder
HIV virus and double-kick therapy
Yuliya Chykunova
Biochemistry & proteases
Haider Ali
HIV virus and double-kick therapy
Jakub Wadas
HIV virus and double-kick therapy
Kinga Lis
Biochemistry & proteases
Students
Kamil Lalik
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Nina Mickiewicz
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Aleksandra Osiecka
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Research tools
Here you will find the major tools we use in our everyday work.
Cell culture
- Human airway epithelium cultures
- Lung and gut organoids
- Cell culture using primary cells
- Complex cell cultures (e.g., with macrophages)
- Dedicated, genetically-modified models
Virology
- Assays with infectious viruses up to BSL3+ category
- VLPs
- Pseudoviruses
- Diverse readout systems (CPE, qPCR, plaque assau, titration, ELISA, WB and others)
