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Research Projects

Current Projects:

  • 2019-2023: Characterization of the role MATR3 in HIV latency and reactivation. NCN Sonata Bis (PI: Anna Kula-Pacurar)
  • 2019-2021: NCN Opus. CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probes and their biochemical analysis. PI: M Sienczyk /Wrocław University of Science and Technology/ (KP: biological research coordinator).
  • 2019-2022. Horizon2020. ITN networks. Organoids for Virus Research - An innovative training-ETN programme. PI for PL and WP coordinator: K Pyrc.
  • 2018-2021. NCN Opus. Cellular proteases during coronaviral infection. PI: K Pyrc.
  • 2018-2021. NCN Opus. Polymer-based systems for inhibition of Zika virus. PI: prof. M Nowakowska [collaboration]
  • 2018-2020. NCN Preludium. Novel inhibitors of herpes virus protease. PI: M Pachota.
  • 2018-2019. NCN Preludium. Analysis of human coronavirus OC43 and Zika virus internalization routes in cells. Inhibition of the early steps of infection by intracellular pH tuning. PI: K Owczarek.
  • 2017-2020: NCN Opus. Zika virus NS3 protease. PI: K Pyrc.
  • 2017-2019: NCN Sonata. Hybrid adsorbents for concentrating, purification and detection viruses. PI: Justyna Ciejka.
  • 2017-2019: NCN Polonez. Molecular dissection of the MATR3/PSF complex in the regulation of HIV-1 posttranscriptional latency: implications for therapy (MATR3PSFHIV) PI: Anna Kula-Pacurar
  • 2013-2019: NCN Sonata bis. Coronavirus and the cell: dyplomatic bag. PI: Krzysztof Pyrc.

Completed projects:

  • 2015-2018: NCN Opus. Novel polyelectrolytes as potential inhibitors of HSV-1 virus - synthesis, properties and mechanism of action. PI: M Nowakowska. (KP: biological research coordinator).
  • 2016-2017: NCN Symfonia. Extracellular proteolytic activity of human epithelium – role in the modulation of signal transduction. PI: J Potempa (KP: workpackagecoordinator).
  • 2015: Internalization of the PEDV virus to the host cell. Diamond grant from the Ministry of Science and Higher Education (PI: Paulina Nowak).
  • 2013-2017: NCN Fuga. Virus Like Particles. PI: A Naskalska.
  • 2013:  Identification of the APOBEC3 cytidine deaminases as an additional human defense system against RNA viruses, on the example of coronaviruses. Preludium Grant from the National Science Centre (PI: Aleksandra Milewska).
  • 2011: Mechanism of HCoV-NL63 / HCoV-HKU1 infection. Extension of the Iuventus Plus grant from the Ministry of Science and Higher Education (PI: Krzysztof Pyrc).
  • 2011: Porphyromonas gingivalis: natural defense and regulatory mechanisms. Research grant from The National Science Centre (PI: Krzysztof Pyrc)
  • 2011: Novel oncolytic vectors. Lider grant from The National Centre for Research and Development (PI: Krzysztof Pyrc).
  • 2010: Mechanism of HCoV-NL63 / HCoV-HKU1 infection. Iuventus Plus grant from the Ministry of Science and Higher Education (PI: Krzysztof Pyrc).
  • 2010: HOMING PROGRAMME (Reintegration Grant For Polish Scientists). Foundation for Polish Science. 09.2010-09.2011 (PI: Krzysztof Pyrc).
  • 2010: Enzymes produced by Porphyromonas gingivalis as virulence factors and potential targets for drug development against periodontitis, rheumatoid arthritis, atherosclerosis and aspiration pneumonia. Foundation for Polish Science (PI prof Jan Potempa; Aspiration pneumonia WP coordinator: Krzysztof Pyrc)
  • 2009: „HexaPrime as a new method for identification of RNA viruses” Research grant from Ministry of Science and Higher Education (PI: Krzysztof Pyrc).
  • 2009: industrial grant together with commercial entities.
  • 2009: „Molecular Biotechnology for Health” within the EU structural funds/POIG 2.1 programme.
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