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Pawel Botwina

Pawel Botwina M.Sc.
PhD Student
Faculty of Biochemistry, Biophysics and Biotechnology
E-mail: pawel.botwina [AT] doctoral.uj.edu.pl

Research interests

  • Development of novel inhibitory compounds against viral diseases.

Education & Experience
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    1. 2016 - : Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University. PhD studies.
    2. 2014-2016 : Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Krakow, Poland (M.Sc. studies)
    3. 2011 - 2014: Jagiellonian University, Faculty of Biology and Earth Sciences, Krakow, Poland (B.Sc. studies)
    4. 2008 - 2011: Maria Curie Sklodowska High School, Jaroslaw, Poland

    1. Botwina, P.; Obłoza, M.; Zatorska-Płachta, M.; Kamiński, K.; Mizusaki, M.; Yusa, S.-I.; Szczubiałka, K.; Pyrc, K.; Nowakowska, M. (2022) Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors. Pharmaceutics, 14, 309.
    2. Sancineto L, Ostacolo C, Ortega-Alarcon D, ALESANCO AJ, Ceballos-Laita L, Vega S, Abian O, Velazquez-Campoy A, Moretti S, Dabrowska A, Botwina P, Synowiec A, KulaPacurar A, Pyrc K, Iraci N, Santi C. (2021) Argine improves solubility and anti SARS-CoV-2 Mpro activity of Rutin but not the antiviral activity in cells. Molecules. 6(19):6062.
    3. Napolitano V, Dabrowska A, Schorpp K, Mourão A, Barreto-Duran E, Benedyk M, Botwina P, Brandner S, Bostock M, Chykunova Y, Czarna A, Dubin G, Fröhlich T, Hoelscher M, Jedrysik M, Matsuda A, Owczarek K, Pachota M, Plettenburg O, Potempa J, Rothenaigner I, Schlauderer F, Szczepanski A, Mohn KGI, Blomberg B, Sattler M*, Hadian K*, Popowicz GM*, Pyrc K*. Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Cell Chemical Biology. in press.
    4. Pyrc K, Milewska A, Baretto Duran E, Botwina P, Lopes R, Arenas-Pinto A, Badr M, Mellor R, Kalber T, Fernandez-Reyes D, Schatzlein AG, Uchegbu IF. (2020). SARS-CoV-2 inhibition in human airway epithelial cells using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray. Scientific Reports. . 11, 20012.
    5. Mazur-Panasiuk N, Botwina P, Kutaj A, Woszczyna D, Pyrc K. (2021) Ozone Treatment Is Insufficient to Inactivate SARS-CoV-2 Surrogate under Field Conditions.  Antioxidants. 10(9):1480.
    6. Mangiavacchi F, Botwina P, Menichetti E, Bagnoli L, Rosati O, Marini F, Fonseca SF, Abenante L, Alves D, Dabrowska A, Kula-Pacurar A, Ortega-Alarcon D, Jimenez-Alesanco A, Ceballos-Laita L, Vega S, Rizzuti B, Abian O, Lenardão EJ, Velázquez-Campoy A, Pyrc K, Sancineto L, Santi C. (2021). Seleno functionalization of quercetin improves the antiviral activity against the SARS-CoV-2 through the non-covalent inhibition of Mpro. International Journal of Molecular Sciences. 22(13):7048.
    7. Milewska A, Chi Y, Szczepanski A, Barreto-Duran E, Dabrowska A, Botwina P, Liu K, Liu D, Guo X, Ge Y, Li J, Cui L, Ochman M, Urlik M, Rodziewicz-Motowidlo S, Zhu F, Szczubialka K, Nowakowska M, Pyrc K. (2021). HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV. Journal of Virology. 95(4):e01622-20.
    8. Botwina P, Obłoza M, Szczepański A, Szczubiałka K, Nowakowska M, Pyrc K. In Vitro Inhibition of Zika Virus Replication with Poly(Sodium 4-Styrenesulfonate). (2020). Viruses. 2020 Aug 23;12(9):E926.
    9. Botwina P, Owczarek K, Rajfur Z, Ochman M, Urlik M, Nowakowska M, Szczubiałka K, Pyrc K. Berberine hampers influenza A replication through inhibition of MAPK/ERK pathway. (2020). Viruses. in press.
    10. Ciejka J, Botwina P, Nowakowska M, Szczubiałka K, Pyrc K. Synthetic sulfonated derivatives of poly(allylamine hydrochloride) as inhibitors of human metapneumovirus. PLoS One. 14(3):e0214646.