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Agnieszka Dabrowska

Agnieszka Dabrowska M.Sc.
PhD Student
Faculty of Biochemistry, Biophysics and Biotechnology
E-mail: agnieszka.dabrowska [AT] doctoral.uj.edu.pl

Research interests

  • Flaviviruses
  • Virus like particles and viral vectors

Supervisor(s)

prof Krzysztof Pyrc 

Education & Experience
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    1. 2016 - : Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University. PhD studies.
    2. 2014 - 2016 : Molecular Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University
    3. 2011-2014: Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University
    4. 2008-2011: Jan III Sobieski High School in Krakow

    1. Sancineto L, Ostacolo C, Ortega-Alarcon D, ALESANCO AJ, Ceballos-Laita L, Vega S, Abian O, Velazquez-Campoy A, Moretti S, Dabrowska A, Botwina P, Synowiec A, Kula-Pacurar A, Pyrc K, Iraci N, Santi C. (2021) Argine improves solubility and anti SARS-CoV-2 Mpro activity of Rutin but not the antiviral activity in cells. Molecules. in press.
    2. Napolitano V, Dabrowska A, Schorpp K, Mourão A, Barreto-Duran E, Benedyk M, Botwina P, Brandner S, Bostock M, Chykunova Y, Czarna A, Dubin G, Fröhlich T, Hoelscher M, Jedrysik M, Matsuda A, Owczarek K, Pachota M, Plettenburg O, Potempa J, Rothenaigner I, Schlauderer F, Szczepanski A, Mohn KGI, Blomberg B, Sattler M*, Hadian K*, Popowicz GM*, Pyrc K*. Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Cell Chemical Biology. in press.
    3. Pyrc K, Milewska A, Baretto Duran E, Botwina P, Lopes R, Arenas-Pinto A, Badr M, Mellor R, Kalber T, Fernandez-Reyes D, Schatzlein AG, Uchegbu IF. (2020). SARS-CoV-2 inhibition in human airway epithelial cells using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray. Scientific Reports. In press.
    4. Sancineto L, Mangiavacchi F, Dabrowska A, Pacuła A, Obieziurska-Fabisiak M, Scimmi C, Lei Y, Kong J, Zhao Y, dos Santos Machado K, Velasque Werhli A, Ciancaleoni G, Nascimento V, Kula-Pacurar A, João Lenardão E, Yang H, Ścianowski J, Pyrc K, Santi C. (2020). Organoselenium mild electrophiles in the inhibition of Mpro and SARS-CoV-2 replication. ChemRxiv. https://doi.org/10.26434/chemrxiv.12994250.v1
    5. Naskalska A, Dabrowska A, Szczepanski A, Jasik KP, Gromadzka B, Pyrc K. (2021) Functional SARS CoV-2 virus-like particles from insect cells. Frontiers in Microbiology. in press.
    6. Milewska A, Chi Y, Szczepanski A, Barreto-Duran E, Dabrowska A, Botwina P, Liu K, Liu D, Guo X, Ge Y, Li J, Cui L, Ochman M, Urlik M, Rodziewicz-Motowidlo S, Zhu F, Szczubialka K, Nowakowska M, Pyrc K. (2020). HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV. Journal of Virology. in press.
    7. Dabrowska A, Milewska A, Ner-Kluza J, Suder P, Pyrc K. Zika virus NS3 protease and its cellular substrates. (2020). Biorxiv. doi: https://doi.org/10.1101/2020.09.18.303867
    8. Pancer K, Milewska A, Owczarek K, Dabrowska A, Kowalski M, Labaj P, Branicki W, Sanak M, Pyrc K. The SARS-CoV-2 ORF10 is not essential in vitro or in vivo in humans. (2020). PLoS Pathogens. in press.
    9. Milewska A, Kula-Pacurar A, Wadas J, Suder A, Szczepanski A, Dabrowska A, Owczarek K, Ochman M, Stacel T, Rajfur Z, Sanak M, Labaj P, Branicki W, Pyrc K. Replication of SARS-CoV-2 in human respiratory epithelium. (2020) Journal of Virology. doi: https://doi.org/10.1101/2020.03.20.999029
    10. Milewska A, Ner-Kluza J, Dabrowska A, Bodzon-Kulakowska A, Pyrc K, Suder P. (2019). Mass spectrometry in virological sciences. Mass Spectrometry Reviews. In press.
    11. Naskalska A, Dabrowska A, Szczepanski A, Milewska A, Jasik K, Pyrc K.  (2019). Membrane protein of HCoV-NL63 is responsible for interaction with the adhesion receptor. Journal of Virology. in press.
    12. Gruba N, Igancio Rodrigez MJ, Wysocka M, Skoreński M, Grzywa R, Dabrowska A, Lecka M, Suder P, Sienczyk M, Pyrc K, Lesner A. (2018). One step beyond: design of substrates spanning primed positions of Zika virus NS2B-NS3 protease. ACS Medicinal Chemistry Letters. in press.
    13. Naskalska A, Dabrowska A, Nowak P, Szczepanski A, Jasik K, Milewska A, Ochman M, Zeglen S, Rajfur Z, Pyrc K. (2018). Novel coronavirus like particles targeting cells lining the respiratory tract. PLoS One. in press.